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Center for the production, research and development of biopharmaceuticals, such as culture media, antianemics, vaccines, technology transfer, allergenic extracts and others. It contributes to the training of university professionals by collaborating with the University of Havana, José Antonio Echeverría Higher Polytechnic Institute and the training of medical specialists from the Universities of Medical Sciences.

Provide customers with the power of knowledge and technological diversity, in order to meet the needs of these with the highest quality and experience.

The National Center of Bio-products (also known by the acronym BIOCEN) is a large scientific-industrial complex dedicated to the manufacture of biopharmaceutical products, including research and development in several lines. Created in 1992, it includes industrial facilities for the production of natural or recombinant proteins, microbiological culture media, as well as formulation, aseptic processing and lyophilization of vaccines and biopharmaceuticals.

BIOCEN is located in the municipality of Bejucal, on the outskirts of Havana, now Mayabeque province, and belongs to the biotechnology center of the Ministry of Science, Technology and Environment.


It provides services for contracts for the production and development of low volume parenteral products, lyophilizates, vaccines and other biotechnological products.
It produces culture media and related products, antianemics and products for the diagnosis and immunotherapy of allergies.

Main activities

This center develops several activities such as:

* Technology transfer.
* Biological tests for product quality control and animal testing for R & D purposes.
* Research and development of new products for microbiological diagnosis, allergy and antianemics.

* Development of biotechnological processes, industrial scaling of biopharmaceutical productions.
* Production and commercialization of allergenic extracts for diagnosis and immunotherapy.
* Production and commercialization of protein hydrolysates that contribute to the solution of food and / or health problems.
* Production and commercialization of culture media and nutritional bases for growth and microbiological diagnosis and plant cultures.
* Quality system that covers all the activities of the center.
* Production of active ingredients for components of vaccines, biopharmaceuticals and other products.
* Productive service of formulation, filling, lyophilization, revision and packaging of low parenteral volume.

In the field of research BioCen works in the development of culture media for the microbiological diagnosis in the development of allergen extracts standardized for the specific diagnosis of allergy, as well as therapeutic vaccines against respiratory allergies. Also works on antianemics and restorative development of natural origin.

Lines of investigation

This institution carries out its research-development work in the following themes:

* Culture media, nutritional bases and supplements for the cultivation of microorganisms.
* Systems for the rapid identification of microorganisms, chromogenic and fluorogenic media.
* Culture media for the in vitro micropropagation of plants of economic interest.
* Re-constituents and antianemics of natural origin. Combination formulations
* Standardized allergen extracts for skin tests and anti-allergic therapeutic vaccines (immunotherapy).
* Anti-monoclonal antibodies against allergens for in-vitro use.
* Recombinant allergens of mites.
* New generation anti-allergy vaccines, based on purified allergens and immunomodulatory adjuvants
* Escalation and development of manufacturing processes of biopharmaceutical and biotechnological products under Good Manufacturing Practices (GMP).

Scientific technical programs and national collaboration

The center participates in different Science and Technical Programs of the country organized by the Ministry of Science and Technology (CITMA) and the Ministry of Public Health (MINSAP). These programs are:

* National Vaccine Program (CITMA).
* Development of Biotech, Pharmaceutical and Green Medicine Products (CITMA).
* National Diagnostic Program (MINSAP).
* Development of the Sugar Industry.
* Agricultural Biotechnology.

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